Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population

Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population

Introduction: Hypertension is a multifactorial disease influenced by genetic and environmental¬†components, with its prevalence varying across ethnic groups. Manifold studies on blood pressure¬†regulatory system genes have been carried out ‚ÄĒsuch as the renin-angiotensin-aldosterone system,¬†the sympath...

Saved in:
Journal Title: Biomédica. Revista del Instituto Nacional de Salud
First author: Diana María Valencia
Other Authors: Carlos Andrés Naranjo;
María Victoria Parra;
María Antonieta Caro;
Ana Victoria Valencia;
Carlos José Jaramillo;
Gabriel Bedoya
Traslated keyword:
Language: Undetermined
Get full text: https://www.revistabiomedica.org/index.php/biomedica/article/view/1489
Resource type: Journal Article
Source: Biomédica. Revista del Instituto Nacional de Salud; Vol 33, No 4 (Year 2013).
DOI:
Publisher: Instituto Nacional de Salud
Usage rights: Otros Ninguna publicaci√≥n, nacional o extranjera, podr√° reproducir ni traducir los art√≠culos ni sus res√ļmenes, sin previa autorizaci√≥n escrita del Comit√© Editorial de la revista Biom√©dica
Subjects: Health Sciences --> Tropical Medicine
Abstract: Introduction: Hypertension is a multifactorial disease influenced by genetic and environmental¬†components, with its prevalence varying across ethnic groups. Manifold studies on blood pressure¬†regulatory system genes have been carried out ‚ÄĒsuch as the renin-angiotensin-aldosterone system,¬†the sympathetic nervous system, endothelial factor, and sodium balance‚ÄĒ, but the results yielded were¬†inconsistent among populations.Objectives: To evaluate the effect of both variants in genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1,¬†ADD2, ATP2B1, TBXA2R PTGS2, and the result of the individual ancestry component on hypertension¬†and blood pressure levels among population in Antioquia.Methods and materials: 107 cases and 253 controls were genotyped for 12 variants on genes¬†AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2, and for 20 ancestry¬†informative markers. The association of polymorphisms and their interactions, and the association of¬†ancestral genetic composition with hypertension and blood pressure levels were examined.Results: Genes ADD2, rs4852706 (OR=3.0; p=0.023); DRD1, rs686 (OR=0.38; p=0.012) and ADRB2,¬†rs1042718 (OR=10.0; p=0.008); as well as genotypic combinations of DRD1 and AGTR1; AGT and¬†ADD1; and ADD1 to ATP2B1 and PTGS2 were associated to hypertension. The Amerindian ancestry¬†component was associated to some decrease in diastolic blood pressure.Conclusion: Variants on genes ADD2, DRD1, ADRB2, AGTR1, AGT, ADD1, ATP2B1 and PTGS2¬†individually or interacting, are associated to hypertension. The Amerindian ancestry component has an¬†effect on blood pressure.doi: http://dx.doi.org/10.7705/biomedica.v33i4.1489
Translated abstract: Introducci√≥n. La hipertensi√≥n arterial es una enfermedad multifactorial influenciada por componentes¬†gen√©ticos y ambientales, cuya prevalencia var√≠a entre grupos √©tnicos. Se han llevado a cabo numerosos¬†estudios en genes de sistemas reguladores de la presi√≥n arterial, como el sistema renina-angiotensina-aldosterona,¬†el sistema nervioso simp√°tico, los factores endoteliales, y el balance de sodio, mostrando¬†resultados incongruentes entre poblaciones.Objetivos. Evaluar el efecto de variantes en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1,¬†ADD2, ATP2B1, TBXA2R y PTGS2 y del componente ancestral individual, sobre la hipertensi√≥n arterial¬†y las cifras de presi√≥n arterial en una muestra de poblaci√≥n antioque√Īa.Materiales y m√©todos. Se genotipificaron 107 casos y 253 controles para 12 variantes en los genes¬†AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2, y para 20 marcadores¬†informativos de ascendencia.¬†Se evalu√≥ la asociaci√≥n de los polimorfismos y sus interacciones, y de la composici√≥n gen√©tica¬†ancestral con hipertensi√≥n y cifras de presi√≥n arterial.Resultados. Los genes ADD2, rs4852706 (OR=3,0; p=0,023); DRD1, rs686 (OR=0,38; p=0,012) y¬†ADRB2, rs1042718 (OR=10,0; p=0,008); y combinaciones genot√≠picas de DRD1 con AGTR1; de AGT¬†con ADD1; y de ADD1 con ATP2B1 y PTGS2, se asociaron con hipertensi√≥n arterial. El componente¬†ancestral amerindio se asoci√≥ con disminuci√≥n en la presi√≥n arterial diast√≥lica.Conclusiones. Variantes en los genes ADD2, DRD1, ADRB2, AGTR1, AGT, ADD1, ATP2B1 y PTGS2,¬†individualmente o en su interacci√≥n, se encuentran asociadas con hipertensi√≥n. El componente¬†ancestral amerindio tiene un efecto sobre las cifras de presi√≥n arterial.¬†doi: http://dx.doi.org/10.7705/biomedica.v33i4.1489