Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration
Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration
Jornal de Investigação Biomédica e Biofarmacêutica
The Stratum corneum is a principal protector against physical, chemical, biological aggression and water loss in human skin. The repeated use of alcohol-based hand sanitizers might result in dryness and aggression. This study aims to evaluate the impact of a four week-long regular use of an alcohol-based gel hand sanitizer on skin hydration on the epidermal ‘barrier’ function using a kinetic model to quantify TEWL desorption curves following a POST test. A group of 13 female (19.7 ± 1.0 years old) washed one of their hands for 29 consecutive days with a commercially available ethanol-based gel sanitizer. TEWL, superficial hydration (SH) and deep hydration (DH) were measured on days 1, 8, 15, 22 and 29, while a continuous TEWL recording following a 24 hour POST was made on days 1, 15 and 29 on a second skin area. No differences were found for the control hand throughout the study. For the test hand an increase of TEWL was found between days 1 and 8, as well as an increase of SH and DH between days 1 and 22. No significant differences were found for the kinetic parameters. These results suggest that the frequent use of the sanitizer gel might alter the skin barrier function.
O estrato córneo é o principal protetor contra a agressão física, química, biológica e perda de água na pele humana. A lavagem repetida das mãos especialmente com desinfetantes à base de álcool pode resultar em secura e agressão. Este estudo tem como objetivo avaliar o impacto do uso regular de quatro semanas de duração de um gel desinfetante para as mãos à base de álcool sobre a hidratação da pele sobre a função de 'barreira' epidérmica usando um modelo cinético para quantificar as curvas de dessorção de PTEA na sequência de um teste POST. Um grupo de 13 mulheres (19,7 ± 1,0 anos de idade) lavaram as mãos durante 29 dias consecutivos com um desinfetante gel à base de etanol disponível no mercado. A PTEA, hidratação superficial (HS) e hidratação profunda (HP) foram medidas nos dias 1, 8, 15, 22 e 29, enquanto a PTEA foi registada continuamente na sequência de um POST de 24h nos dias 1, 15 e 29 numa segunda zona da pele . Não foram encontradas diferenças para a mão de controlo ao longo do estudo. Para a mão teste foi encontrado um aumento de PTEA entre os dias 1 e 8, bem como um aumento de SH e DH entre os dias 1 e 22. Nenhuma diferença significativa foi encontrada com os parâmetros cinéticos. Estes resultados sugerem que o uso frequente do gel desinfetante para as mãos pode alterar a função de barreira da pele.
Bibliographic data
Translated title: | Avaliação do impacto do uso regular (4 semanas) de um gel desinfetante na PTEA e hidratação epidérmica |
---|---|
Journal Title: | Jornal de Investigação Biomédica e Biofarmacêutica |
First author: | Henrique Silva |
Other Authors: | Liliana Tavares; Rita Faria; Stefânia Delsin; Luis Monteiro Rodrigues |
Palabras clave: | |
Traslated Keywords: | |
Language: | English Portuguese |
Get full text: | http://www.alies.pt/BBR%20Editions/Vol-12-2-2015/art8_vf.pdf |
Resource type: | Journal Article |
Source: | Jornal de Investigação Biomédica e Biofarmacêutica; Vol 12, No 2 (Year 2015). |
DOI: | http://dx.doi.org/10.19277/bbr.12.2.121 |
Publisher: | Associação Lusófona para o Desenvolvimento da Investigação e Ensino em Ciências da Saúde |
Usage rights: | Reconocimiento - NoComercial (by-nc) |
Categories: | Life Sciences --> Biochemistry --AMP-- Molecular Biology Health Sciences --> Pharmacology --AMP-- Pharmacy Health Sciences, Life Sciences --> Physiology |
Statistical data
- Views
- Consultations
- Citation style
- Share
- Export record
- Favourites
Bibliography: | 1. Rosado C, Ferreira J, Pinto PC, Rodrigues LM . Skin barrier function evaluation by bicompartmental analysis of tewl dynamical measurements: validation of new analytical conditions. Biomed Biopharm Res 2012; (9) 2: 183-189. 2. Larson EL, Early E, Cloonan P, Sugrue S, Parides M. An organizational climate intervention associated with increased handwashing and decreased nosocomial infections. Behav Med 2000; 26:14–22. 3. Boyce JM, Pittet D; Healthcare Infection Control Practices Advisory Committee, HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR Recomm Rep 2002; 51(RR16):1–45. 4. Löffler H, Kampf G, Schmermund D, Maibach HI. How irritant is alcohol? Br J Dermatol 2007; 157(1):74-81. 5. Houben E, De Paepe K, Rogiers V. Skin condition associated with intensive use of alcoholic gels for hand disinfection: a combination of biophysical and sensorial data. Contact Dermatitis 2006; 54(5):261-7. 6. Lotte C, Rougier A, Wilson DR, Maibach HI. In vivo relationship between transepidermal water loss and percutaneous penetration of some organic compounds in man: effect of anatomic site. Arch Dermatol Res 1987; 279: 351–356. 7. Rosado C, Rodrigues LM. Assessment of dry skin using dynamic methods. J. Appl. Cosmetol 2006; 24: 139-157. 8. Berardesca E, Fideli D, Gabba P, Cespa M, Rabbiosi G, Maibach HI. Ranking of surfactant skin irritancy in vivo in man using the plastic occlusion stress test (POST). Contact Dermatitis 1990; 23 (1):1–5. 9. Pinto P, Rosado C, Parreirão C, Rodrigues LM. Is there any barrier impairment in sensitive skin?: a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves. Skin Res Technol 2011; 17(2):181-5. 10. Rodrigues LM, Silva H., Rosado C, Regarding the quantification of the human skin barrier in Sensitive Skin Syndrome, Honari G, Andersen R, Maibach HI, eds. Sensitive Skin Syndrome, second edition, CRC Press: Boca Raton (in press). 11. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human volunteers. JAMA; 310(20):2191-4. 12. Silva H, Silva SA, Ferreira H, Rodrigues LM. Assessing the in vivo impact of a gel sanitizer on the epidermal "barrier" dynamics. Biomed Biopharm Res 2015; (12) 1: 69- 77. 13. Rodrigues LM, Pinto PC, Galego N, Da Silva PA, Pereira LM. Transepidermal water loss kinetic modeling approach for the parameterization of skin water dynamics. Skin Res Technol 1999; 5:72–82. 14. Rosado C, Pinto P, Rodrigues LM. Modeling TEWL-desorption curves: a new practical approach for the quantitative in vivo assessment of skin barrier. Exp Dermatol 2005; 14(5):386-90. 15. Dal'Belo SE, Gaspar LR, Maia Campos PM. Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Res Technol. 2006;12(4):241-6. |
---|