Pharmacology of Natural Products: An recent approach on Calotropis gigantea and Calotropis procera
Pharmacology of Natural Products: An recent approach on Calotropis gigantea and Calotropis procera
Ars Pharmaceutica
Introduction: Since ancient times, people have used medicinal plants to treat varied diseases. Medicinal plants are the important source of drugs, and many of them that are currently available in the pharmaceutical market are obtained from plant sources. Calotropis gigantea and Calotropis procera are small shrub, which are used conventionally to treat many diseases such as cancer, diabetes and intestinal disease in African and Asian countries. There have been always an increased focus on primary health care: basic health care which is effective and affordable by developing countries. Objective: This paper aims to review the pharmacological and pharmacognostical features of Calotropis gigantea and Calotropis procera Method: Brief review on recent literature carried out using Scopus, Google scholar. Result and Discussion: Several studies provide evidence of their antioxidant, analgesic, anti-inflammatory, anti-diarrheal, anticonvulsant, anti-malarial, hepatoprotective, antitumor, antimicrobial and anti-nociceptive properties. Conclusion: Species of Calotropis not widely recognized showed different pharmacological actions, due to the presence of effective secondary metabolites.
Introducción: Desde la antigüedad, las personas han utilizado plantas medicinales para tratar diversas enfermedades. Las plantas medicinales son la fuente importante de los fármacos, y muchas de ellas, que están actualmente disponibles en el mercado farmacéutico, se obtienen de fuentes vegetales. Calotropis gigantea y Calotropis procera son arbustos pequeños que se utilizan convencionalmente para tratar muchas enfermedades como el cáncer, la diabetes y las enfermedades intestinales en países africanos y asiáticos. Siempre se ha prestado una mayor atención a la Atención Primaria de salud: la atención básica de la salud es eficaz y asequible para los países en desarrollo. Objetivos: Este trabajo tiene como objetivo revisar las características farmacológicas y farmacognosóticas de Calotropis gigantea y Calotropis procera. Método: Breve revisión de la literatura reciente realizada utilizando Scopus, Google scholar. Resultado y discusión: Varios estudios proporcionan evidencia de sus propiedades antioxidantes, analgésicas, antiinflamatorias, antidiarreicas, anticonvulsivas, antipalúdicas, hepatoprotectoras, antitumorales, antimicrobianas y anti-nociceptivas. Conclusión: Especies de Calotropis no ampliamente reconocido mostraron diferentes acciones farmacológicas, debido a la presencia de metabolitos secundarios efectivos.
Dados bibliográficos
| Título traduzido: | Farmacología de productos naturales: un enfoque reciente en Calotropis gigantea y Calotropis procera |
|---|---|
| Título da revista: | Ars Pharmaceutica |
| Primer autor: | Shripad M. Bairagi |
| Outros autores: | Prashant Ghule; Rit Gilhotra |
| Palavras chave: | |
| Palavras chave traducidas: | |
| Idioma: | Inglês |
| Ligação recurso: | https://revistaseug.ugr.es/index.php/ars/article/view/7276 |
| Tipo de recurso: | Artigo de revista |
| Fonte: | Ars Pharmaceutica; Vol 59, No 1 (Ano 2018). |
| DOI: | http://dx.doi.org/10.30827/ars.v59i1.7276 |
| Entidade editora: | Universidad de Granada |
| Direitos de utilização: | Reconocimiento - NoComercial - CompartirIgual (by-nc-sa) |
| Matérias: | Ciências da Saúde --> Farmácia e Farmacologia |
Dados estatísticos
- Visualizações
- Consultas
- Estilo Citação
- Partilhar
- Exportar registo
- Favoritos
| Bibliografia: | Kiritikar K, Basu B. Indian Medicinal Plants. Int B Distrib. 1987;III(2 Edn):1432–6. Bairagi SM, Aher AA, Nema N, Pathan IB. Evaluation of anti-diarrhoeal activity of the leaves extract of Ficus Microcarpa L. (Moraceae). Marmara Pharmaceutical Journal. 2014;3(18):135-135. Doi:10.12991/mpj.2014187240 Rahimi M. Pharmacognostical Aspects and Pharmacological activities of Calotropis procera. Bulletin of Environment, Pharmacology and Life Sciences. 2015;4(2):156-162. Nalwaya N, Pokharna G, Deb L, Jain NK. Wound healing activity of latex of Calotropis gigantea. International Journal of Pharmacy and Pharmaceutical Sciences. 2009;(1):176–81. Arya S, Kumar VL. Antiinflammatory efficacy of extracts of latex of Calotropis procera against different mediators of inflammation. Mediators of Inflammation. 2005;2005(4):228–32. Doi:10.1155/MI.2005.228 Verma VN. The chemical study of Calotropis. International Letters of Chemistry, Physics and Astronomy. 2014;1:74-90. 10.18052/www.scipress.com/ILCPA.20.74 Oloumi H. Phytochemistry and Ethno-Pharmaceutics of Calotropis procera. Ethno-Pharmaceutical Products. 2014;1(2):1–8. Joseph B, George J, Jeevitha M V, Charles S. Pharmacological and biological overview on Calotropis gigantea: a comprehensive review. International Research Journal Pharmaceutical and Applied Sciences [Internet]. 2013;3(5):219-223, 5 . Available from: http://www.irjpas.com/zip.php?file=File_Folder/IRJPAS 3(5)219-223.pdf&id=308&quat=3 Sharma AK, Kharb R, Kaur R. Pharmacognostical aspects of Calotropis procera (Ait.) R. Br. International Journal of Pharma and Bio Sciences. 2011;2(3):480–8. Parihar G, Sharma A, Ghule S, Sharma P, Deshmukh P, Srivastava DN. Anti inflammatory effect of Calotropis procera root bark extract . Asian Journal of Pharmacy and Life Science. 2011;1(1):29–44. Evans WC. Trease and Evans’ Pharmacognosy.2005:41-47. Habib MR, Karim MR. Antimicrobial and Cytotoxic Activity of Di-(2-ethylhexyl) Phthalate and Anhydrosophoradiol- 3-acetate Isolated from Calotropis gigantea (Linn.) Flower. Korean Society of Mycology. 2009;37(1):31–6. Radhakrishnan K, Thangamani P, Balakrishnan V. Antibacterial and phytochemical analysis of stem and root extracts of Calotropis gigantea against selected pathogens. Malaya Journal of Biosciences. 2014;1(1):49–55. Available from: http://www.malayabiosciences.com/download.php?id=10 Mohamed NH, Ismail MA, Abdel-Mageed WM, Mohamed Shoreit AA. Antimicrobial activity of latex silver nanoparticles using Calotropis procera. Asian Pacific Journal of Tropical Biomedicine . 2014;4(11):876–83. Doi:10.12980/APJTB.4.201414B216, Available from: http://linkinghub.elsevier.com/retrieve/pii/S2221169115300344 Kumar VL, Basu N. Anti-inflammatory activity of the latex of Calotropis procera. Journal of Ethnopharmacology. 1994;44(2):123–5. Rahman R, Rahman F, Shashank B, Rajasshekar S, Gangadhar B, Chandrashekhar S, Evaluation of Calotropis Gigantea root in experimental diarrhoea. International Journal of Pharmacy & Industrial Research. 2012; 2(1):10-15. Murti Y, Singh SP, Devender P. Comparison of anti-diarrheal activity of hydroethanolic extract of Calotropis Procera and Calotropis Gigantea leaves. Journal ofPharmaceutical and Scientific Innovation. 2012 ;1(4):32-33. Lodhi G, Singh HK, Pant KK, Hussain Z. Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats. Acta Pharmaceutica. 2009;59(1):89–96. Doi: 10.2478/v10007-009-0002-2. Ramachandra Setty S, Quereshi AA, Viswanath Swamy AHM, Patil T, Prakash T, Prabhu K, et al.. Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia. 2007;78(7–8):451–4. Doi:10.1016/j.fitote.2006.11.022 Sayed AELD, Mohamed NH, Ismail MA, Abdel-Mageed WM, Shoreit AAM. Antioxidant and antiapoptotic activities of Calotropis procera latex on Catfish (Clarias gariepinus) exposed to toxic 4-nonylphenol. Ecotoxicology and Environmental Safety. 2016;128:189–94. Doi: 10.1016/j.ecoenv.2016.02.023 Habib MR, Karim MR. Effect of anhydrosophoradiol-3-acetate of Calotropis gigantea (Linn.) flower as antitumoric agent against Ehrlich’s ascites carcinoma in mice, Pharmacological Reports. 2013; 65: 761-767. Habib MR, Karim MR. Evaluation of antitumour activity of Calotropis gigantea L. root bark against Ehrlich ascites carcinoma in Swiss albino mice. Asian Pacific Journal of Tropical Medicine. 2011;4(10):786–90. Doi:10.1016/S1995-7645(11)60194-6. Mathur R, Gupta SK, Mathur SR, Velpandian T. Anti-tumor studies with extracts of Calotropis procera (Ait.) R.Br. root employing Hep2 cells and their possible mechanism of action. Indian Journal of Experimental Biology. 2009;47(5):343–8. Iqbal Z, Lateef M, Jabbar A, Muhammad G, Khan MN. Anthelmintic activity of Calotropis procera (Ait.) Ait. F. flowers in sheep. Journal of Ethnopharmacology. 2005;102(2):256–61. Doi: 10.1016/j.jep.2005.06.022 Dongare SD, Mali SS, Dhanawade PP, Patrekar PV. In-vitro anthelmintic activity of Calotropis Gigantea against Indian earth worm Pheretima Posthuma. International Journal of Institutional Pharmacy and Life Sciences.2015;5(1):117-123. Singh K, Rao V, Hussain Z, Pahuja. Evaluation of anti-diabetic and antioxidant activity of extract of Calotropis Gigantea linn in streptozotocin induced diabetic rats. The Pharma Innovation. 2014; 2(11):1-12. Mário C.L. Neto, Carlos F. B. de Vasconcelos, Valerium N. Thijan, Germana F. R. Caldas, Alice V. Araujo, Joao H. Costa-Silva. Evaluation of antihyperglycaemic activity of Calotropis Procera leaves extract on streptozotocin-induced diabetes in wistar rats. Revista Brasileira Farmacognosia. 2013;23:913-919. Doi: 10.1590/S0102-695X2013000600008. Tour NS, Talele GS. Gastric antiulcer and anti-inflammatory activities of Calotropis Procera stem bark. Revista Brasileira Farmacognosia Brazilian Journal Pharmacognosy. 2011;21(6): 1118-1126. Doi:10.1590/S0102- 695X2011005000175. Kshirsagar A. Patil PA, Purnima A, Hulkoti B. Anti-inflammatory and anti-ulcer effects of Calotropis Gigantea R. Br. Flowers on rodent. Journal of Natural Remedies. 2008; 8(2):183-190. Doi:10.18311/jnr/2008/332 Raquel Cristina de Sousa Lima , Márcia Calheiros Chaves Silva , Carlos Clayton Torres Aguiar, Edna Maria Camelo Chaves, Katia Cilene Ferreira Dias, Danielle Silveira Macedo. Anticonvulsant action of Calotropis procera latex proteins. Epilepsy & Behavior. 2012; 23: 123–126. Doi:10.1016/j.yebeh.2011.11.008 Ghule SD, Vidyasagar G, Bhandari A, Sharma P, Gunjal AP. CNS activity of leaves extract of Calotropis gigantea. Asian Pacific Journal of Tropical Disease. 2014;4(S2):S902–5. Doi:10.1016/S2222-1808(14)60755-6 Mudi SY, Bukar A. Anti-plasmodia activity of leaf extract of Calotropis Procera linn. Biokemostri, Nigeria. 2011;23(1):29-34. Dhivya R, Manimegalai K, Mosquito repellent activity of Calotropis gigantea (Apocynaceae) flower extracts against the filarial vector Culex Quinquefasciatus. Hygeia:Journal For Drugs And Medicine. 2013; 5 (2): 56-62. Deshmukh PT, Fernandes J, Atul A, Toppo E. Wound healing activity of Calotropis gigantea root bark in rats. Journal of Ethnopharmacology. 2009;125(1):178–81. Doi: 10.1016/j.jep.2009.06.007 Rasik AM, Raghubir R, Gupta A, Shukla A, Dubey MP, Srivastava S, et al.. Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacology. 1999;68(1–3):261–6. |
|---|